Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes
نویسندگان
چکیده
منابع مشابه
Alpha-synuclein spreading in Parkinson’s disease
Formation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson's disease (PD), the aggregation-prone protein alpha-synuclein (α-syn) is the culprit. In the past few years, another piece of the puzzle has been added with data suggesting that α-syn may self-propagate, thereby contributing to the progression and extension of PD...
متن کاملThe Interplay between Alpha-Synuclein Clearance and Spreading
Parkinson's Disease (PD) is a complex neurodegenerative disorder classically characterized by movement impairment. Pathologically, the most striking features of PD are the loss of dopaminergic neurons and the presence of intraneuronal protein inclusions primarily composed of alpha-synuclein (α-syn) that are known as Lewy bodies and Lewy neurites in surviving neurons. Though the mechanisms under...
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BACKGROUND Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using detergent extraction methods [2], [3], [4]. A number of in vitro studies showed that dopamine can modulate the aggregation of alpha-synuc...
متن کاملFunctionalization of α-synuclein fibrils
The propensity of peptides and proteins to form self-assembled structures has very promising applications in the development of novel nanomaterials. Under certain conditions, amyloid protein α-synuclein forms well-ordered structures - fibrils, which have proven to be valuable building blocks for bionanotechnological approaches. Herein we demonstrate the functionalization of fibrils formed by a ...
متن کاملThe fold of -synuclein fibrils
The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases. In Parkinson’s disease it is believed that the aggregation of -synuclein ( -syn) from monomers by intermediates into amyloid fibrils is the toxic diseasecausative mechanism. Here, we studied the structure of -syn in its amyloid state by using various biophysical approaches. Quenched hydrogen/...
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ژورنال
عنوان ژورنال: Brain
سال: 2019
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awz296